Optimized human cell products for research
and drug discovery

iPS Reprogramming

Chief Scientific Officer Professor Ludovic Vallier previously established the Cambridge hIPSC Core Facility and Sanger hIPSC platform – generating 100’s lines for the European Stem Cell bank. Our iPS reprogramming platform is modelled on these high performance facilities. DefiniGEN are a partner in European stem cell bank deriving and validating iPS lines for both pharma and academia. We use integrative and non-integrative methods to reprogram a range of human blood or fibroblast samples generating hIPSC which are fully QCed.

 

Definigen iPS Reprogramming

 

5 step process for the generation of your hIPSC lines

Definigen iPS Reprogramming

 

We can then use complementary services including CRISPR gene-editing and differentiation using our OptiDIFF platform to generate custom models for clients

iPS Reprogramming projects are typically completed within 2-3 months. Actual timelines will vary depending on the unique aspects of each bespoke project.

Selected platform publications

Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Mononuclear Cells Using Sendai Virus. Soares FA, Pedersen RA, Vallier L. Methods Mol Biol. 2016;1357:23-31

Genetic background drives transcriptional variation in human induced pluripotent stem cells. Rouhani F, Kumasaka N, de Brito MC, Bradley A, Vallier L, Gaffney D. PLoS Genet. 2014 Jun 5;10(6):e1004432

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