Production Scientist - Definigen

Production Scientist

Salary: Competitive plus benefits including pension and share options

Location: Babraham Research Campus, Cambridge, UK

Type: Permanent, Full time Start: Immediate

Closing date: 25th February 2021

About us:

DefiniGEN are an exciting, high growth Cambridge UK Biotechnology Company who aim to become a market leader in the provision of stem cell products and CRISPR gene-editing services to the life science sectors. DefiniGEN uses its proprietary OptiDIFF production platform to robustly generate human cell types, including liver hepatocytes and pancreatic cells, from Induced Pluripotent Stem Cells (IPSCs).

DefiniGEN operate a manufacturing pipeline to first gene edit and then differentiate stem cells in order to generate it’s portfolio of disease models, this position is within the differentiation team in which the majority of the work is connected with the culture and differentiation of human iPSCs.

About you:

This is an early-career laboratory-based position which can be tailored for the right candidate, typically it would be suitable for either a new graduate or someone with around three years of post-graduate experience of stem cell biology and mammalian tissue culture.  Experience in the culture of human stem cells (ideally iPSC) and their differentiation (particularly to liver cells) would be particularly advantageous, however full training will be given.

Key Responsibilities:

  • Prepare working cell banks of iPSCs from master cell bank stocks.
  • Conduct cellular differentiation protocols on wild type and gene edited iPSCs.
  • Cryopreserve banks of differentiated cells and assist with their QC assessment.
  • Assist with the general process improvement and trouble shooting of the process.
  • Prepare stocks of tissue culture media and other reagents required by the pipeline.
  • Carry out general laboratory house keeping and cleaning duties.
  • Assist the project managers with the generation of  project summaries and reports


  • Degree in Life Sciences (E), with understanding of stem cell technology (D)
  • Experience of mammalian tissue culture (E), ideally iPSC (D)
  • Capable of working to a schedule and delivery of a variety of challenging projects at a time within agreed deadlines
  • Ability to work both as part of a team and independently when required
  • Good communication skills


Weekend working will be required, and this is currently carried out by a rota system.

Applicants should apply by sending their cover letter and CV to:


Share this page