Def-PANC MODY3 Cell Morphology
Genetic information and phenotypic response confirm Def-PANC MODY3 cells are an effective model of Monogenic Diabetes.
Figure 1. Def-PANC MODY3 cells display aberrant morphology in both monolayer and islet culture.
Disease Circuit Verification
MODY3 pancreatic disease model with mutation in HNF1-alpha transcription factor gene – insertion of C at codon 872 producing frameshift mutation – isogenic control available.
Figure 2. P291 in exon 4. Insertion of C Heterozygous line available
GLUT + PKLR Expression Analysis
Figure 3. Heterozygous and homozygous Def-PANC MODY3 cells show progressive gene change effects in key HNF1a gene regulated genes including PKLR and GLUT-2.
Pancreatic Key Marker Analysis
Figure 4. Key marker analysis by qPCR shows reduction in key pancreatic cell markers in the Def-PANC disease models.
Scientific Poster: Poster_Definigen_ISSCR 2016
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