Disease Modeling
DefiniGEN Laboratory

Disease Modeling

Delivering phenotypically relevant disease models

Liquid Nitrogen

Overview

DefiniGEN's induced pluripotent stem cell (iPSC) OptiDIFF platform enables the generation of high-quality wild-type and disease cell models. We can produce mature cells which recapitulate a range of disease phenotypes and are being adopted for preclinical evaluation studies.

We have developed various disease models for a wide range of rare metabolic indications such as:

DefiniGEN offer the ability to develop custom disease models for screening or characterizing lead compounds for indications that have previously been difficult to study.

Liquid Nitrogen

CRISPR Modeling

  • Rapid turnaround time. Our optimized protocols and standardized workflows ensure fast, efficient project completion.
  • High success rates. Our deep expertise handling challenging iPSCs easily translates into successful CRISPR editing of iPSCs.
  • Collaborative project management. We conduct every project with complete transparency and in close collaboration with client teams to ensure we deliver what you need.
petri dish under microscope

Patient-derived Model

  • Access to rare and metabolic disease samples. Our established relationships with well-regarded cell banks can streamline patient sample sourcing for your project.
  • High success rates. Our optimized iPSC generation and differentiation workflows and years of experience directly translate into higher probabilities for success.
  • Collaborative project management. We conduct every project with complete transparency and in close collaboration with client teams to ensure we deliver what you need.

Frequently Asked Questions

Disease Modeling

  • It depends on the complexity of the project but generally we deliver the edited cell line in 8 weeks. If differentiation into a specific cell type is required, additional time will be necessary and will depend on the requested scale and cell type of interest.

  • The entire gene editing process takes between 8-10 weeks depending on the complexity of the project. We will advise you of the lead time when we generate your quote.

  • We work as a research partner offering collaborative services. We offer bi-weekly calls with our clients and interim emails with project reports. Our team is always available to provide technical support which can include experimental design and training on best practices for handling cells.

  • To generate a quote, we need your name, the name of your organization, your email address and details on the gene, mutation of interest, and cell type to edit. We also recommend contacting our team to go through project requirements in more detail. Contact us today >