Patient Derived Models
DefiniGEN’s patient-derived iPSC custom cell model development service utilizes our proprietary OptiDIFF platform to generate highly functional terminally differentiated cells to fit client specifications. DefiniGEN can source a disease patient sample for iPSC line generation or use an existing from a range of cell banks.
It is known that genetic variability in donors can influence the capacity of donor material to generate truly pluripotent lines that can effectively differentiate in to “end” cell types.
DefiniGEN projects are structured to ensure the client receives their desired custom patient-derived iPSC cell disease model by using multiple donors and clonal lines with the lines being assessed and ranked at each stage to ensure that the best line is used in large scale custom cell model production.