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DefiniGEN’s induced pluripotent stem cell (iPSC) differentiation platform generates high quality wild-type and disease cell models. We can produce mature hepatocytes which recapitulate a range of disease phenotypes. We provide off-the-shelf iPSC derived hepatocytes, but we also offer the ability to model various diseases.
Our hepatocytes are highly functional human hepatocyte cells which have normal genetics (wild type donor + karotype verified). The cells display the functional characteristics of primary human hepatocytes including: albumin production, A1AT secretion, glycogen storage, CYP450 expression.
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells.Yusa K, Rashid ST, Vallier L, et al. Nature. 2011 Oct 12;478(7369):391-4.