We can produce mature hepatocytes which recapitulate a range of disease phenotypes

DefiniGEN hepatocytes are functionally mature hepatocytes which can be plated and functionally maintained over a +20 day window with similar function to primary human hepatocytes PHH.

DefiniGEN disease modelled NAFLD hepatocytes represent an optimized model for drug discovery applications and a principal tool for elucidating the underlying mechanisms of the disease.

DefiniGEN provide disease modelled glycogen storage disease type 1a hepatocytes which are highly functional patient-derived human hepatocytes.

DefiniGEN provide disease modelled alpha-1 antitrypsin deficiency hepatocytes which are highly functional patient-derived human hepatocytes.

DefiniGEN provide disease modelled familial hypercholesterolemia hepatocytes which are highly functional CRISPR gene-edited human hepatocytes.

From a basic frameshift knock-out mutation to complex knock-in genetic changes, our dedicated scientific team will work collaboratively with you to design the right tools to accelerate your research programs.