Patient Derived Models
We can produce mature hepatocytes which recapitulate a range of disease phenotypes
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Explore our hepatocyte products
DefiniGEN iPSC-derived hepatocytes are functionally mature hepatocytes which can be plated and functionally maintained over a +20 day window with similar function to primary human hepatocytes PHH.
DefiniGEN disease modelled NAFLD iPSC-derived hepatocytes represent an optimized model for drug discovery applications and a principal tool for elucidating the underlying mechanisms of the disease.
DefiniGEN provide disease modelled glycogen storage disease type 1a iPSC-derived hepatocytes which are highly functional patient-derived human hepatocytes.
DefiniGEN provide disease modelled alpha-1 antitrypsin deficiency iPSC-derived hepatocytes which are highly functional patient-derived iPSC human hepatocytes.
DefiniGEN provide disease modelled familial hypercholesterolemia iPSC-derived hepatocytes which are highly functional CRISPR gene-edited human hepatocytes.
Custom model development
From a basic frameshift knock-out mutation to complex knock-in genetic changes, our dedicated scientific team will work collaboratively with you to design the right tools to accelerate your research programs.
Advance your scientific discoveries with our tailored disease modeling products and services
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Leverage our robust gene editing process that delivers physiologically relevant disease models to advance your discoveries
Disease modeling products
We offer a collaborative partnership with our clients to deliver models in a timely and efficient manner
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