Hepatocytes

We can produce mature hepatocytes which recapitulate a range of disease phenotypes

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Explore our hepatocyte products

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  Hepatocyte WT

  DefiniGEN iPSC-derived hepatocytes are functionally mature hepatocytes which can be plated and functionally maintained over a +20 day window with similar function to primary human hepatocytes PHH.

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  NAFLD

  DefiniGEN disease modelled NAFLD iPSC-derived hepatocytes represent an optimized model for drug discovery applications and a principal tool for elucidating the underlying mechanisms of the disease.

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  GSD1a

  DefiniGEN provide disease modelled glycogen storage disease type 1a iPSC-derived hepatocytes which are highly functional patient-derived human hepatocytes.

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  A1AT

  DefiniGEN provide disease modelled alpha-1 antitrypsin deficiency iPSC-derived hepatocytes which are highly functional patient-derived iPSC human hepatocytes.

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  FH

  DefiniGEN provide disease modelled familial hypercholesterolemia iPSC-derived hepatocytes which are highly functional CRISPR gene-edited human hepatocytes.

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  Custom model development

  From a basic frameshift knock-out mutation to complex knock-in genetic changes, our dedicated scientific team will work collaboratively with you to design the right tools to accelerate your research programs.

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Advance your scientific discoveries with our tailored disease modeling products and services

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Bespoke services

Leverage our robust gene editing process that delivers physiologically relevant disease models to advance your discoveries

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Disease modeling products

We offer a collaborative partnership with our clients to deliver models in a timely and efficient manner

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