We can produce mature hepatocytes which recapitulate a range of disease phenotypes
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DefiniGEN iPSC-derived hepatocytes are functionally mature hepatocytes which can be plated and functionally maintained over a +20 day window with similar function to primary human hepatocytes PHH.
DefiniGEN disease modelled NAFLD iPSC-derived hepatocytes represent an optimized model for drug discovery applications and a principal tool for elucidating the underlying mechanisms of the disease.
DefiniGEN provide disease modelled glycogen storage disease type 1a iPSC-derived hepatocytes which are highly functional patient-derived human hepatocytes.
DefiniGEN provide disease modelled alpha-1 antitrypsin deficiency iPSC-derived hepatocytes which are highly functional patient-derived iPSC human hepatocytes.
DefiniGEN provide disease modelled familial hypercholesterolemia iPSC-derived hepatocytes which are highly functional CRISPR gene-edited human hepatocytes.
Custom model development
From a basic frameshift knock-out mutation to complex knock-in genetic changes, our dedicated scientific team will work collaboratively with you to design the right tools to accelerate your research programs.
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Leverage our robust gene editing process that delivers physiologically relevant disease models to advance your discoveries
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Disease modeling products
We offer a collaborative partnership with our clients to deliver models in a timely and efficient manner
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