Recent News

Mon, Jun 3, 2024
DefiniGEN and Atelerix collaborate to ship in vitro cell models internationally without the need for freezing or cryopreservation

Latest resource

Wed, Nov 13, 2024
Developing iPSC-Derived Liver Systems for MASLD Modeling and Therapy Screening

Opti-HEP: iPSC-derived Human Hepatocytes

Physiologically relevant liver disease models that can be generated at scale for disease modeling, assay development and screening applications.

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Disease Modeling

DefiniGEN's platform technology enables the generation of predictive and phenotypically relevant iPSC-derived human disease models for a wide range of metabolic and liver diseases which can be produced at scale.

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Profiling Molecules

Combine our expertise at generating iPSC-derived hepatocyte disease models with our wide panel of bespoke bioassays. We work as partners with your team to design and implement in-house screening of small molecules and advanced genetic therapies, so you can advance your program at speed.

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Donor Variance Panel

DefiniGEN has a large panel of iPSC lines allowing us to offer all our disease models and cell-based bioassays in donors ranging in gender, age and ethnicity.  Researchers use our donor panels to further screen their lead candidates and potentially inform the stratification of a successful clinical trial.

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Specialist CRO focused on delivering liver and metabolic disease models

Highly Predictive

Opti-HEPs successfully recapitulate key aspects of disease pathophysiology across a wide-range of conditions that affect different aspects of liver function

Scalable

DefiniGEN’s proprietary differentiation protocol permits large-scale generation of hepatocyte-like cells with field leading purity and functionality

Optimized Bioassay Development

Optimized bioassays that can accurately evaluate compound potency, efficacy and delivery

Scientific expertise

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Advance your scientific discoveries with our tailored disease modeling products and services