Profiling drug candidates

for liver disease

Generating pre-clinical human data for therapeutic candidates with in-vitro liver and metabolic disease models.

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Enabling cures for liver disease through highly predictive in vitro modeling

We generate high-quality, phenotypically relevant disease modeled hepatocytes that can be utilized to screen compounds.

Human Hepatocyte-Like Cells

Physiologically relevant liver disease models that can be generated at scale for disease modeling, assay development and screening applications.

 

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Disease Modeling

DefiniGEN's platform technology enables the generation of predictive and phenotypically relevant iPSC-derived human disease models for a wide range of metabolic and liver diseases which can be produced at scale.

 

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Profiling Drug Candidates

Combine our expertise at generating iPSC-derived hepatocyte disease models with our wide panel of bespoke bioassays. We work as partners with your team to design and implement in-house screening of small molecules and advanced genetic therapies, so you can advance your program at speed.

 

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Donor Variance Panel

DefiniGEN has a large panel of iPSC lines allowing us to offer all our disease models and cell-based bioassays  in donors ranging in gender, age and ethnicity.  Researchers use our donor panels to further screen their lead candidates and potentially inform the stratification of a successful clinical trial.

 

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Specialist CRO focused on delivering liver and metabolic disease models

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Highly Predictive

Hepatocyte-like cells successfully recapitulate key aspects of disease pathophysiology across a wide-range of conditions that affect different aspects of liver function.

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Scalable

 

DefiniGEN’s proprietary differentiation protocol permits large-scale generation of hepatocyte-like cells with field leading purity and functionality.

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Optimized Bioassay Development

Optimized bioassays that can accurately evaluate compound potency, efficacy and delivery.

Scientific expertise

15
Successful and recurring partnerships with leading cell and gene therapy companies 
10
10 years of iPSC
innovation
6
in-house validated disease models ready for screening 
10
10 years of supporting R&D with our innovative, proprietary iPSC endodermal protocols
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Advance your scientific discoveries with our tailored disease modeling products and services.
Screening Services
Disease Modeling