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Shaping the Future of Liver Research and Toxicology
Fully functional iPSC-derived hepatocyte models (Opti-HEP) for generating pre-clinical human data
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Enabling cures for liver disease through highly predictive in vitro modeling
We generate high-quality, phenotypically relevant disease modeled hepatocytes that can be utilized to screen compounds.
Disease Modeling
DefiniGEN's platform technology enables the generation of predictive and phenotypically relevant iPSC-derived human disease models for a wide range of metabolic and liver diseases which can be produced at scale.
![disease-modelling-image](https://www.definigen.com/hs-fs/hubfs/Definigen/disease-modelling-image.png?width=529&height=330&name=disease-modelling-image.png)
Profiling Molecules
Combine our expertise at generating iPSC-derived hepatocyte disease models with our wide panel of bespoke bioassays. We work as partners with your team to design and implement in-house screening of small molecules and advanced genetic therapies, so you can advance your program at speed.
![phenotypic-screening-image](https://www.definigen.com/hs-fs/hubfs/Definigen/phenotypic-screening-image.png?width=529&height=330&name=phenotypic-screening-image.png)
Specialist CRO focused on delivering liver and metabolic disease models
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Highly Predictive
Opti-HEPs successfully recapitulate key aspects of disease pathophysiology across a wide-range of conditions that affect different aspects of liver function.
![icons_dark blue3](https://www.definigen.com/hs-fs/hubfs/icons_dark%20blue3.png?width=90&name=icons_dark%20blue3.png)
Scalable
DefiniGEN’s proprietary differentiation protocol permits large-scale generation of hepatocyte-like cells with field leading purity and functionality.
![icons_dark blue](https://www.definigen.com/hs-fs/hubfs/icons_dark%20blue.png?width=90&name=icons_dark%20blue.png)
Optimized Bioassay Development
Optimized bioassays that can accurately evaluate compound potency, efficacy and delivery.
Scientific expertise
Successful and recurring partnerships with leading cell and gene therapy companies
10 years of iPSC
innovation
in-house validated disease models ready for screening
10 years of supporting R&D with our innovative, proprietary iPSC endodermal protocols
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