Advance your candidate program at speed
Through the provision of phenotypically relevant human data
Leverage our drug discovery expertise
DefiniGEN's Phenotypic Screening Service helps you move quickly and efficiently from screening library to promising candidates by combining our expertise at generating iPSC-derived hepatocyte cellular models of disease with our wide panel of bespoke bioassays.
We work as partners with your team to design and implement in-house screening of small molecules, RNAi/oligonucleotide therapeutics, AAVs and virtually any modality so you can advance your program at speed.
Why choose DefiniGEN?
When you choose DefiniGEN's efficacy screening services, you don't just get access to extra hands and fully equipped labs, we become your scientific partners providing experience in many aspects of the drug discovery process and cell-based assays, including assay development, lead optimization, and RNAi formulation. We aim to work with your team collaboratively to ensure that you get the most informative and actionable data as efficiently as possible.
Advance any therapeutic modality
RNAi therapeutics, small molecules, gene therapeutics
Experts in gene therapy
We have 7+ years of successfully completed projects that we continue to build on
Bespoke modelling services available
Use pre-made or custom iPSC-derived hepatocyte models to fit your project specific requirements
Optimized Bioassay development
Quantify cell viability, proliferation, apoptosis and more. Leverage our fully equipped labs and drug discovery expertise
In-house drug screening platform capabilities, advancing your programme at speed
Using our OptiDIFF platform technology alongside CRISPR gene-editing capabilities, we can generate a wide range of disease models to support hit to lead compound profiling initiatives.
And, of course you get access to our proprietary OptiDIFF platform, which is well known for generating iPSC-derived models for even "difficult" target cell types such as hepatocytes, intestinal cells and organoids.
Technology
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Flow cytometers
Confocal microscopes
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Fluorescence intensity (incl. FRET)
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Fluorescence polarization,
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Luminescence (flash and glow) - incl. BRET,
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Time-resolved fluorescence, TR-FRET,
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UV/vis absorbance spectra
qPCR profiling
Phenotypic Assays
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Cell viability
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LDH (cell death/ cytotoxicity)
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Reactive oxygen species assay
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PAS/Diastase staining
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BODIPY fatty acid accumulation
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Copper accumulation
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FOCI A1AT assay
Project workflow
01
Project consultation - Choose/develop a model
Our team of experts will structure a study according to your project specific requirements.
02
Select your assay and send us your compounds
Depending on your therapeutic modality, our team optimize treatment windows and dosing accordingly.
03
We work as a research partner
Offering bi-weekly updates and interim reporting.
In-house drug screening platform capabilities
Move even faster by screening your candidates on our already built and ready-to-use validated models.
Let’s work together.
Contact us to arrange a free consultation to discuss your project requirements today.