Advance your candidate
program at speed
Through the provision of phenotypically relevant human data
Leverage our drug discovery expertise
DefiniGEN's Phenotypic Screening Service helps you move quickly and efficiently from screening library to promising candidates by combining our expertise at generating iPSC-derived hepatocyte cellular models of disease with our wide panel of bespoke bioassays.
We work as partners with your team to design and implement in-house screening of small-molecule and RNAi/oligonucleotide therapeutics, so you can advance your program at speed.
Why choose DefiniGEN?
When you choose DefiniGEN's phenotypic screening service, you don't just get access to extra hands and fully equipped labs, we become your scientific partners providing experience in many aspects of the drug discovery process and cell-based assays, including assay development, lead optimization, and RNAi formulation. We aim to work with your team collaboratively to ensure that you get the most informative and actionable data as efficiently as possible.
In-house drug screening platform capabilities, advancing your programme at speed
Using our OptiDIFF platform technology alongside CRISPR gene-editing capabilities, we can generate a wide range of disease models to support hit to lead compound profiling initiatives.
And, of course you get access to our proprietary OptiDIFF platform, which is well known for generating iPSC-derived models for even "difficult" target cell types such as hepatocytes, intestinal cells and organoids, and pancreatic cells.
Fluorescence intensity (incl. FRET)
Luminescence (flash and glow) - incl. BRET,
Time-resolved fluorescence, TR-FRET,
UV/vis absorbance spectra
LDH (cell death/ cytotoxicity)
Reactive oxygen species assay
BODIPY fatty acid accumulation
FOCI A1AT assay
In-house drug screening platform capabilities
Move even faster by screening your candidates on our already built and ready-to-use validated models.
Custom model development
Let’s work together.
Contact us to arrange a free consultation to discuss your project requirements today.